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Schematic presentation of molecular events leading to astrocytic differentiation and apoptosis in glioblastoma cells after treatment with combination of 4-HPR and IFN-γ. Treatment with 4-HPR could down regulate hTERT, CDK2 and pRb, which would most likely result in cell cycle arrest. Prolongation of cell cycle arrest would enhance sensitivity of the cells to IFNγ for activation of caspase cascades for apoptosis.
