Table 2.
Semi-quantitative analysis of the expression levels of the mediators for inflammation in lining and sublining layer of synovial tissue in the patients
| Mediator | Layer | K/L 2 or 3 (n = 4) | K/L 4 (n = 19) |
p |
|---|---|---|---|---|
| MMP-1 | Lining | 2.0 (0.8, 0.7–3.3) | 1.0 (0.6, 0.7–1.3) | 0.03* |
| Sublining | 2.1 (0.6, 1.1–3.1) | 1.0 (0.5, 0.7–1.2) | 0.01* | |
| COX-2 | Lining | 1.4 (0.7, 0.2–2.5) | 0.5 (0.3, 0.3–0.7) | 0.01* |
| Sublining | 0.9 (0.4, 0.3–1.4) | 0.3 (0.3, 0.1–0.4) | 0.01* | |
| IL-1β | Lining | 2.1 (0.7, 1.0–3.2) | 1.1 (0.6, 0.9–1.4) | 0.02* |
| Sublining | 2.0 (0.5, 1.1–2.8) | 1.2 (0.4, 1.0–1.4) | 0.02* | |
| NF-κB1 | Lining | 1.5 (0.4, 0.9–2.2) | 1.1 (0.5, 0.8–1.3) | 0.08 |
| Sublining | 1.3 (0.4, 0.7–2.0) | 1.2 (0.6, 0.79–1.5) | 0.51 | |
| TGF-β | Sublining | 0.1 (0.1, −0.1 to 0.2) | 0.6 (0.3, 0.5–0.8) | <0.01* |
K/L Kellgren-Lawrence grade
Data are presented as the mean (standard deviation [SD], 95% confidence interval [CI] of the mean)
* p value is significant