Table 1.

Prediction accuracy of chemosensitivity/resistance in NCI-60 cell lines using 28-gene breast cancer prognostic signature. A P-value < 0.05 represents the overall accuracy is significantly higher than that of random prediction (two-sided Z-tests).

Drug name	Sensitivity (chemoresistance)	Specificity (chemosensitivity)	Overall Accuracy	P Value
Tamoxifen	94.4% (17/18)	85.7% (12/14)	90.6% (29/32)	0.0004
Fluorouracil (5FU; part of CMF)	76.5% (13/17)	88.2% (15/17)	82.4% (28/34)	0.005
Methotrexate (part of CMF)	60.0% (12/20)	84.0% (21/25)	73.3% (33/45)	0.02
Paclitaxel (Taxol)	86.7% (13/15)	100% (11/11)	92.3% (24/26)	0.0008
Doxorubicin (Adriamycin)	100% (19/19)	77.8% (14/18)	89.2% (33/37)	0.0002
Docetaxel	94.4% (17/18)	81.3% (13/16)	88.2% (30/34)	0.0007