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miRNAs regulate DSB DDR through modulating the core protein components of various pathways. The key proteins during the DDR pathway are summarized in the order of sensors/mediators, transducers and effectors, while the effectors include DNA repair, cell-cycle checkpoint (G1/S, intra-S and G2/M) and apoptosis mechanisms. Interactions with miRNAs that regulate the expression of DDR protein components are indicated in red.
