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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Exp Gerontol. 2011 Feb 2;46(6):441–452. doi: 10.1016/j.exger.2011.01.005

Figure 6.

Figure 6

skn-1 is required for the enhanced longevity of DATS treated worms. (A) TJ1060 (spe-9(hc88); fer-15(b26)) or LG335 (skn-1(zu135)/nT1[qIs51]) worms were grown on NGA plates. Day 1 adult spe-9(hc88); fer-15(b26) and skn-1(zu135) mutant worms were transferred to new plates spotted with DMSO or 10 μM DATS, and the adult lifespan measured by touch provoked movement. (B) LG348 (skn-1(zu135)/nT1[qIs51];geIs9[gpa-4p::skn-1b::gfp]) worms, which express the skn-1b isoform only in ASI neurons, were grown on NGA plates. Day 1 adult skn-1(zu135) mutant worms were transferred to new plates spotted with DMSO or 10 μM DATS, and the adult lifespan measured by touch provoked movement. (C) LG357 (skn-1(zu135)/nT1[qIs51];geIs10[ges-1p::skn-1c::gfp]) worms, which express the skn-1c isoform only in the intestine, were grown on NGA plates. Day 1 adult skn-1(zu135) mutant worms were transferred to new plates spotted with DMSO or 10 μM DATS, and the adult lifespan measured by touch provoked movement.