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. Author manuscript; available in PMC: 2012 May 25.
Published in final edited form as: J Am Chem Soc. 2011 May 3;133(20):7648–7651. doi: 10.1021/ja2006719

Figure 4.

Figure 4

(a) Schematic representation of the reaction of PRMT1 Y39FM48G mutant, Pob-SAM cofactor 5 and human histone H4 substrate. (b) ESI-MS spectrum of the modified H4. (c) Tandem mass spectrum of a characteristic H4R3 fragment.