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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Pharmacol Res. 2011 Apr 2;64(1):60–67. doi: 10.1016/j.phrs.2011.03.007

Figure 2.

Figure 2

Effect of intraplantar injection of JZL184 on mechanical hyperalgesia. A. JZL184 attenuated tumor-evoked mechanical hyperalgesia (F3,169=18.42, p<0.001, two-way ANOVA). Mechanical hyperalgesia was confirmed before drug administration (PD=pre-drug). B. Co-administration of the CB2 receptor antagonist AM630 (4 μg) with JZL184 (10 μg) eliminated the anti-hyperalgesia produced by JZL184. Co-administration with the CB1 receptor antagonist AM281 (10 μg) had no effect on the antihyperalgesic effect of JZL184. *Different at p<0.05, one-way ANOVA with Bonferroni’s t-test, number inside bar represents sample size).