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. Author manuscript; available in PMC: 2012 Jun 6.
Published in final edited form as: FEBS Lett. 2011 May 6;585(11):1657–1662. doi: 10.1016/j.febslet.2011.04.060

Figure 1.

Figure 1

The role of SIRT1 in mediating adaptive responses to limited energy intake. SIRT1 mediates adaptive responses to acute and chronic energy limitation, such as fasting and diet restriction, and maintains the robustness of our physiological system by increasing blood glucose levels, utilizing fatty acid as an alternative energy source, and triggering neurobehavioral regulatory pathways in multiple tissues indicated.