Table 1.
| Baseline Characteristics | DEFUSE (n=74) | EPITHET (n=100) | p value |
|---|---|---|---|
| Female | 57% | 44% | 0.096 |
| Mean age ± SD | 71 ± 15 | 71 ± 13 | 0.779 |
| Hypertension | 45 (61%) | 71 (71%) | 0.159 |
| Diabetes mellitus | 20 (27%) | 22 (22%) | 0.444 |
| Hyperlipidemia | 18 (24%) | 40 (40%) | 0.030 |
| Current or past smoker | 31 (42%) | 37 (37%) | 0.513 |
| Median NIHSS (IQR) | 12 (8, 16) | 13 (8, 18) | 0.419 |
| Mean time to treatment in min ± SD | 324 ± 36 | 296 ± 46 | < 0.001 |
| Median baseline original DWI volume mL (IQR) | 10 (3, 27) | 20 (8, 45) | 0.001 |
| Median baseline RAPID DWI volume mL (IQR) | 6 (1, 22) | 12 (5, 33)a | 0.031 |
| Median baseline original PWI volume mL (IQR) | 49 (6, 97)b | 164 (87, 255)c | < 0.001 |
| Median baseline RAPID PWITmax>6 volume (IQR) | 34 (5, 86)b | 65 (23, 132)d | 0.003 |
| Median baseline original mismatch volume mL (IQR) | 26 (0, 69)b | 126 (60, 214)c | < 0.001 |
| Median baseline RAPID mismatch volume mL (IQR) | 16 (0, 68)b | 37 (12, 81)e | 0.003 |
|
| |||
|
Clinical outcomes at day 90
| |||
| Median NIHSS (IQR) | 4 (1, 12) | 5 (2, 16)c | 0.260 |
| mRS 0–2 | 37 (50%) | 42 (42%)c | 0.322 |
| mRS 0–1 | 25 (34%) | 30 (30%)c | 0.627 |
a
Data for 98 patients;
b
data for 67 patients;
c
data for 99 patients;
d
data for 95 patients;
e
data for 94