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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Dev Biol. 2011 Apr 17;355(1):12–20. doi: 10.1016/j.ydbio.2011.04.007

Figure 4. Defective lens cell differentiation in NdstCKO mutants.

Figure 4

(A–F) In the E12.5 NdstCKO mutant, transcription factors Pax6 and Prox1 were misexpressed in the posterior and anterior lens vesicle, respectively. Consistent with this, the whole lens vesicle retains the lens epithelial marker, E-Cadherin. (G–L) Ectopic Pax6, Prox1 and E–Cadherin expression was reduced but still detectable at E14.5 (arrowheads). (M–R) α-, β-, and γ-Crystallins were present in the E14.5 NdstCKO mutant lens, but their levels appeared reduced compared to wild type controls (arrowheads). Three embryos of each genotype were tested for each staining.