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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Dev Biol. 2011 Apr 17;355(1):12–20. doi: 10.1016/j.ydbio.2011.04.007

Figure 7. Kras signaling reversed the Ndst mutant phenotype.

Figure 7

(A–F)The delay in lens fiber elongation in the E13.5 NdstCKO mutant (B, arrowhead) was reversed by activation of Kras signaling in the NdstCKO;LSL-KrasG12D lens (C, arrow). Consistent with this phenotypic rescue, phospho-ERK staining was also restored in the NdstCKO;LSL-KrasG12D lens (compare E and F, arrow and arrowhead). (G) Quantification of lens size. [One way ANOVA test: P<0.01 for the NdstCKO mutants (n=8) compared to either the wild type (n=10) or the NdstCKO;LSL-KrasG12D (n=10).]