Table I.

Comparison of Folding Time Changes, Contacts, and ln(k_f) for Different Regions of CI2 and src SH3 Domain

	CI2					Src SH3
Window	Structure	Locala	Nonlocalb	%Δc	ln (kf)d	Structure	Local	Nonlocal	%Δ	ln (kf)
0	unconstrained			100	−11.8	unconstrained			100	−11.7
1		2	5	94	−11.7		1	4	115	−11.9
2		3	4	94	−11.7		1	9	48	−11
3		3	5	59	−11.2	RT loop (extended 1)	1	11	49	−11
4	strands 1/2	2	9	47	−11.0		2	12	49	−11
5		3	10	42	−10.9		1	13	62	−11.3
6		3	12	52	−11.1		2	12	101	−11.8
7		2	15	50	−11.1		5	9	138	−12.1
8		5	13	61	−11.3		8	6	99	−11.7
9		7	12	56	−11.2	RT loop (turn)	9	5	100	−11.7
10		6	15	56	−11.2		9	7	83	−11.6
11		8	14	78	−11.5		4	14	76	−11.5
12		10	14	94	−11.7		2	16	73	−11.4
13	helix	9	14	93	−11.7		0	17	98	−11.7
14		9	22	107	−11.8	RT loop (extended 2)	2	15	49	−11
15		9	22	105	−11.8		3	13	44	−10.9
16		9	22	79	−11.5		5	8	41	−10.8
17		9	20	78	−11.5		5	5	33	−10.6
18		9	17	113	−11.9		4	3	31	−10.6
19		9	15	94	−11.7		2	5	31	−10.6
20		9	13	77	−11.5		0	10	34	−10.7
21		9	10	72	−11.4		0	14	28	−10.5
22		6	11	64	−11.3		1	14	32	−10.6
23		1	14	66	−11.3	n-src loop (strand)	1	13	28	−10.5
24		1	12	67	−11.4		1	12	60	−11.2
25	strand 3	1	12	31	−10.6		2	9	78	−11.5
26		0	12	35	−10.7		4	7	84	−11.6
27		0	10	31	−10.6	n-src loop (turn)	8	3	81	−11.5
28		0	8	34	−10.7		9	2	72	−11.4
29		1	5	22	−10.3		6	7	76	−11.5
30		2	2	34	−10.7		2	16	51	−11.1
31		3	0	36	−10.7		1	20	57	−11.2
32		3	1	37	−10.7		0	22	50	−11
33		3	3	34	−10.7	distal hairpin (strand 1)	0	22	59	−11.2
34		1	7	30	−10.6		1	20	54	−11.1
35		0	10	38	−10.8		3	16	84	−11.6
36		0	12	45	−11.0		7	7	70	−11.4
37		0	12	55	−11.2	distal hairpin (turn)	10	2	81	−11.5
38		0	11	73	−11.4		10	2	82	−11.5
39	functional loop	4	6	91	−11.7		5	7	61	−11.2
40		5	4	76	−11.5		1	14	67	−11.3
41		8	1	65	−11.3		0	15	41	−10.8
42		6	4	46	−11.0		0	15	35	−10.7
43		4	9	37	−10.8		0	14	41	−10.8
44		2	16	25	−10.4		1	11	52	−11.1
45	strand 4	0	21	31	−10.6		3	6	84	−11.6
46		0	21	41	−10.9		6	2	56	−11.2
47		0	21	51	−11.1		6	0	58	−11.2
48		1	16	50	−11.1		6	0	79	−11.5
49		4	12	56	−11.2
50		8	4	50	−11.1
51		10	2	65	−11.3
52		8	4	52	−11.1
53		3	9	80	−11.5
54		1	12	69	−11.4
55	strands 5/6	1	12	45	−10.9
56		1	12	57	−11.2
57		1	11	69	−11.4

^aNumber of local contacts made within the window.

^bNumber of nonlocal contacts made between the window and outside residues.

^cMedian folding time as a percent of unconstrained median folding time.

^dk_f is in units of simulation steps.