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. 2010 Oct 13;30(41):13729–13738. doi: 10.1523/JNEUROSCI.2939-10.2010

Figure 5.

Figure 5.

Neurturin deprivation results in loss of surface N-terminal APP and caspase 6 activation. A, Immunofluorescent microscopic analysis using an antibody to the APP N terminus demonstrated the patchy loss of surface APP (sAPP) on axons of SCG neurons deprived of Neurturin. B, Active caspase 6 was detected in SCG axons via visualization with carboxyfluorescein within 20 h after Neurturin withdrawal. C, Quantitative analysis of axonal degeneration in SCG neurons deprived of Neurturin. Note that treatment with caspase 6 inhibitor (VEID-CHO) or expression of Bcl-xl or cytNmnat1 protects against axonal degeneration induced by Neurturin withdrawal. *Significantly different (p<0.001, Student's t test) from neurons grown in the presence of Neurturin.