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. 2011 May 2;12(1):60. doi: 10.1186/1465-9921-12-60

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Copyright ©2011 Dahal et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of inhibiting c-kit and MC degranulation on PH and right ventricular hypertrophy (RVH) of MCT-rats. Rats were treated with selective c-kit inhibitor (PLX), MC stabilizer (Cromolyn) or placebo from day 1 to 21 after MCT-injection. The rats in healthy group received saline injection instead of MCT. (A) Right ventricular systolic pressure (RVSP), (B) Right to left ventricular plus septum weight ratio (RV/(LV+S)) and (C) Systemic arterial pressure (SAP)are given. Each bar represents Mean ± SEM (n = 8-10). *p < 0.05 versus healthy; ^†p < 0.05 versus MCT-placebo.