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. Author manuscript; available in PMC: 2011 May 31.
Published in final edited form as: Neuron. 2011 Apr 14;70(1):43–50. doi: 10.1016/j.neuron.2011.02.044

Figure 4. Postsynaptic LTP Is Normal, whereas Postsynaptic LTD Is Blocked.

Figure 4

(A) EPSC amplitudes were significantly (p < 0.005 for all groups) increased following LTP induction (arrow) in PICK1 KO (red), GluR2Δ7 KI (blue), and GluR2K882A KI (green) mutants, but these increases were not significantly different from those in controls (black). (B) LTD induction in slices of 3- to 6-month-old PICK1 KO, GluR2Δ7 KI, and GluR2K882A KI mutants was significantly impaired compared to that of controls. (C) Even after application of the LTP blocker cyclosporin A, LTD induction did not occur in the mutants. Insets show that the ratio of paired pulse facilitation after induction of plasticity to that before induction (PPF-R) did not change in control, PICK KO, GluR2Δ7 KI, and GluR2K882A KI mice, suggesting that plasticity occurred post-synaptically. For clarity of presentation the wild-types are presented as a pooled group. Number of mice per group is listed in Table S1, and p values, in Table S2. Scale bars: horizontal, 30 ms; vertical, 100 pA. Error bars denote SEM.

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