Table 2.
Variables names and comments.
| Randomisation data | |
|---|---|
| HOSPNUM | Hospital number |
| RDELAY | Delay between stroke and randomisation in hours |
| RCONSC | Conscious state at randomisation (F - fully alert, D - drowsy, U - unconscious) |
| SEX | M = male; F = female |
| AGE | Age in years |
| RSLEEP | Symptoms noted on waking (Y/N) |
| RATRIAL | Atrial fibrillation (Y/N); not coded for pilot phase - 984 patients |
| RCT | CT before randomisation (Y/N) |
| RVISINF | Infarct visible on CT (Y/N) |
| RHEP24 | Heparin within 24 hours prior to randomisation (Y/N) |
| RASP3 | Aspirin within 3 days prior to randomisation (Y/N) |
| RSBP | Systolic blood pressure at randomisation (mmHg) |
| RDEF1 | Face deficit (Y/N/C=can't assess) |
| RDEF2 | Arm/hand deficit (Y/N/C=can't assess) |
| RDEF3 | Leg/foot deficit (Y/N/C=can't assess) |
| RDEF4 | Dysphasia (Y/N/C=can't assess) |
| RDEF5 | Hemianopia (Y/N/C=can't assess) |
| RDEF6 | Visuospatial disorder (Y/N/C=can't assess) |
| RDEF7 | Brainstem/cerebellar signs (Y/N/C=can't assess) |
| RDEF8 | Other deficit (Y/N/C=can't assess) |
| STYPE | Stroke subtype (TACS/PACS/POCS/LACS/OTH=other) |
| RDATE | Year and month of randomisation (yyyy-mm) |
| HOURLOCAL | Local time - hours (99-missing data) of randomisation |
| MINLOCAL | Local time - minutes (99-missing data) of randomisation |
| DAYLOCAL | Estimate of local day of week; 1 - Sunday, 2-Monday, 3-Tuesday, 4-Wednesday, 5-Thursday, 6-Friday, 7-Saturday |
| RXASP | Trial aspirin allocated (Y/N) |
| RXHEP | Trial heparin allocated (M/L/N). The terminology for the allocated dose of unfractioned heparin changed slightly from the pilot to the main study. Patients were allocated either 12500 units subcutaneously twice daily (coded as H in the pilot and M in the main trial), 5000 units twice daily (coded as L throughout) or to 'avoid heparin' (coded as N throughout). |
| Data collected on 14 day/discharge form about treatments given in hospital | |
| DASP14 | Aspirin given for 14 days or till death or discharge (Y/N/U=unknown) |
| DASPLT | Discharged on long term aspirin (Y/N/U=unknown) |
| DLH14 | Low dose heparin given for 14 days or till death/discharge (Y/N/U=unknown) |
| DMH14 | Medium dose heparin given for 14 days or till death/discharge (Y/N/U=unknown) |
| DHH14 | Medium dose heparin given for 14 days etc in pilot (combine with above; Y/N) |
| ONDRUG | Estimate of time in days on trial treatment |
| DSCH | Non trial subcutaneous heparin (Y/N/U=unknown) |
| DIVH | Non trial intravenous heparin (Y/N/U=unknown) |
| DAP | Non trial antiplatelet drug (Y/N/U=unknown) |
| DOAC | Other anticoagulants (Y/N/U=unknown) |
| DGORM | Glycerol or manitol (Y/N/U=unknown) |
| DSTER | Steroids (Y/N/U=unknown) |
| DCAA | Calcium antagonists (Y/N/U=unknown) |
| DHAEMD | Haemodilution (Y/N/U=unknown) |
| DCAREND | Carotid surgery (Y/N/U=unknown) |
| DTHROMB | Thrombolysis (Y/N/U=unknown) |
| DMAJNCH | Major non-cerebral haemorrhage (Y/N/U=unknown) |
| DMAJNCHD | Date of above (days elapsed from randomisation) |
| DMAJNCHX | Comment on above |
| DSIDE | Other side effect (Y/N/U=unknown) |
| DSIDED | Date of above (days elapsed from randomisation) |
| DSIDEX | Comment on above |
| Final diagnosis of initial event | |
| DDIAGISC | Ischaemic stroke (Y/N/U=unknown) |
| DDIAGHA | Haemorrhagic stroke (Y/N/U=unknown) |
| DDIAGUN | Indeterminate stroke (Y/N/U=unknown) |
| DNOSTRK | Not a stroke (Y/N/U=unknown) |
| DNOSTRKX | Comment on above |
| Recurrent stroke within 14 days | |
| DRSISC | Ischaemic recurrent stroke (Y/N/U=unknown) |
| DRSISCD | Date of above (days elapsed from randomisation) |
| DRSH | Haemorrhagic stroke (Y/N/U=unknown) |
| DRSHD | Date of above (days elapsed from randomisation) |
| DRSUNK | Unknown type (Y/N/U=unknown) |
| DRSUNKD | Date of above (days elapsed from randomisation) |
| Other events within 14 days | |
| DPE | Pulmonary embolism; (Y/N/U=unknown) |
| DPED | Date of above (days elapsed from randomisation) |
| DALIVE | Discharged alive from hospital (Y/N/U=unknown) |
| DALIVED | Date of above (days elapsed from randomisation) |
| DPLACE | Discharge destination (A-Home/B-Relatives home/C-Residential care/D-Nursing home/E-Other hospital departments/U-Unknown) |
| DDEAD | Dead on discharge form (Y/N/U=unknown) |
| DDEADD | Date of above (days elapsed from randomisation); NOTE: this death is not necessarily within 14 days of randomisation |
| DDEADC | Cause of death (1-Initial stroke/2-Recurrent stroke (ischaemic or unknown)/3-Recurrent stroke (haemorrhagic)/4-Pneumonia/5-Coronary heart disease/6-Pulmonary embolism/7-Other vascular or unknown/8-Non-vascular/0-unknown) |
| DDEADX | Comment on death |
| Data collected at 6 months | |
| FDEAD | Dead at six month follow-up (Y/N/U=unknown) |
| FLASTD | Date of last contact (days elapsed from randomisation) |
| FDEADD | Date of death (days elapsed from randomisation); NOTE: this death is not necessarily within 6 months of randomisation |
| FDEADC | Cause of death (1-Initial stroke/2-Recurrent stroke (ischaemic or unknown)/3-Recurrent stroke (haemorrhagic)/4-Pneumonia/5-Coronary heart disease/6-Pulmonary embolism/7-Other vascular or unknown/8-Non-vascular/0-unknown) |
| FDEADX | Comment on death |
| FRECOVER | Fully recovered at 6 month follow-up (Y/N/U=unknown) |
| FDENNIS | Dependent at 6 month follow-up (Y/N/U=unknown) |
| FPLACE | Place of residance at 6 month follow-up (A-Home/B-Relatives home/C-Residential care/D-Nursing home/E-Other hospital departments/U-Unknown) |
| FAP | On antiplatelet drugs at six month follow-up (Y/N/U=unknown) |
| FOAC | On oral anticoagulants at six month follow-up (Y/N/U=unknown) |
| Other data and derived variables | |
| FU1_RECD | Date discharge form received (days elapsed from randomisation) |
| FU2_DONE | Date 6 month follow-up done (days elapsed from randomisation) |
| COUNTRY | Abbreviated country code |
| CNTRYNUM | Country code (see Table 1) |
| FU1_COMP | Date discharge form completed (days elapsed from randomisation) |
| NCCODE | Coding of compliance (see Table 3) |
| CMPLASP | Compliant for aspirin (N/Y) |
| CMPLHEP | Compliant for heparin (N/Y) |
| ID | Indicator variable for death (1 = died; 0 = did not die) |
| TD | Time of death or censoring in days |
| EXPDD | Predicted probability of death/dependence at 6 month |
| EXPD6 | Predicted probability of death at 6 month |
| EXPD14 | Predicted probability of death at 14 days |
| SET14D | Know to be dead or alive at 14 days (1 = Yes, 0 = No); this does not necessarily mean that we know outcome at 6 months - see OCCODE for this |
| ID14 | Indicator of death at 14 days (1 = Yes, 0 = No) |
| OCCODE | Six month outcome (1-dead/2-dependent/3-not recovered/4-recovered/0 or 9 - missing status |
| Indicator variables for specific causes of death | |
| DEAD1 | Initial stroke (1 = Yes, 0 = No) |
| DEAD2 | Reccurent ischaemic/unknown stroke (1 = Yes, 0 = No) |
| DEAD3 | Reccurent haemorrhagic stroke (1 = Yes, 0 = No) |
| DEAD4 | Pneumonia (1 = Yes, 0 = No) |
| DEAD5 | Coronary heart disease (1 = Yes, 0 = No) |
| DEAD6 | Pulmonary embolism (1 = Yes, 0 = No) |
| DEAD7 | Other vascular or unknown (1 = Yes, 0 = No) |
| DEAD8 | Non vascular (1 = Yes, 0 = No) |
| H14 | Cerebral bleed/heamorrhagic stroke within 14 days; this is slightly wider definition than DRSH and is used for analysis of cerebral bleeds; (1 = Yes, 0 = No) |
| ISC14 | Indicator of ischaemic stroke within 14 days (1 = Yes, 0 = No) |
| NK14 | Indicator of indeterminate stroke within 14 days (1 = Yes, 0 = No) |
| STRK14 | Indicator of any stroke within 14 days (1 = Yes, 0 = No) |
| HTI14 | Indicator of haemorrhagic transformation within 14 days (1 = Yes, 0 = No) |
| PE14 | Indicator of pulmonary embolism within 14 days (1 = Yes, 0 = No) |
| DVT14 | Indicator of deep vein thrombosis on discharge form (1 = Yes, 0 = No) |
| TRAN14 | Indicator of major non-cerebral bleed within 14 days (1 = Yes, 0 = No) |
| NCB14 | Indicator of any non-cerebral bleed within 14 days (1 = Yes, 0 = No) |