TABLE 1 .
Microarray-based global gene expression profiles for the M1-SDHHBtail mutant strain versus the wild-type M1-SF370 strain showing the number of significantly differentiated genes belonging to different functional categories
| Functional category of genes |
Total no. of significantly differentiated genesa |
% of significantly differentiated genes |
No. of upregulated genes |
No. of downregulated genes |
|---|---|---|---|---|
| Amino acid transport and metabolism |
11 | 5.7 | 3 | 8 |
| Carbohydrate transport and metabolism |
37 | 19.3 | 1 | 36 |
| Cell division and chromosome partition |
1 | 0.5 | 1 | 0 |
| Cell envelope and biogenesis |
2 | 1.04 | 0 | 2 |
| Cell motility and secretion |
1 | 0.5 | 0 | 1 |
| Coenzyme metabolism | 3 | 1.6 | 0 | 3 |
| DNA replication and recombination |
4 | 2.1 | 3 | 1 |
| Energy production and conversion |
14 | 7.3 | 3 | 11 |
| Function unknown | 36 | 18.8 | 10 | 26 |
| General function prediction only |
15 | 7.8 | 5 | 10 |
| Inorganic ion transport |
1 | 0.5 | 0 | 1 |
| Lipid metabolism | 12 | 6.3 | 11 | 1 |
| Nucleotide transport and metabolism |
4 | 2.1 | 4 | 0 |
| Phage | 15 | 7.8 | 10 | 5 |
| Posttranslational modification | 5 | 2.6 | 3 | 2 |
| Secondary metabolite biosynthesis |
5 | 2.6 | 2 | 3 |
| Transcription | 5 | 2.6 | 1 | 4 |
| Translation and ribosomal structure |
4 | 2.1 | 2 | 2 |
| Virulence genes | 18 | 9.4 | 5 | 13 |
| Total no. (%) | 192 | 100 | 64 (33.3) | 128 (66.7) |
a
The total number of significantly differentiated genes for the different functional categories of genes and the totals are shown in boldface type.