TABLE 3 .

Differentially expressed genes encoding virulence factors in the M1-SDH_HBtail mutant strain^a

M1-SF370 ORF	Gene	Annotation	Microarray median log2 ratio	P value
SPy0165	nga	Nicotine adenine dinucleotide glycohydrolase precursor	−2.35	0.001
SPy0167	slo	Streptolysin O precursor	−2.25	0.001
SPy0428	spyA	C3 family ADP-ribosyltransferase	−1.29	0.003
SPy0436	speJ	Putative exotoxin (superantigen)	−1.24	0.004
SPy0738 to -746	sagA-sagI	Streptolysin S-associated ORF	−2.25 to −4.18	0.0002 to 3.72E−-06
SPy1972	pulA	Putative pullulanase	−1.16	0.0238
SPy1979	ska	Streptokinase A precursor	−1.50	0.0041
SPy1983	scl	Collagen-like surface protein	−5.59	4.94E−09
SPy1985	rgfB	Exodeoxyribonuclease III	−1.96	0.0044
SPy2016	sic	Inhibitor of complement-mediated lysis	−2.13	4.76E−07
SPy2018	emm1	M-protein type 1	−1.13	0.0121
SPy2039	speB	Pyrogenic exotoxin B	−2.81	0.0007
SPy2043	mf	Mitogenic factor	−1.83	0.0016
SPy2200 to -2202	hasA-hasC	Hyaluronate synthase, UDP-G-6-D, UDP-GPPIaseb	−4.32 to−4.49	1.29 to 1.72 E−08
SPy0711	speC	Pyrogenic exotoxin C precursor, phage associated	1.54	0.0012
Spy0712	mf2	Putative DNase, phage associated	1.69	0.0012
Spy0737	epf	Putative extracellular matrix-binding protein	3.45	0.0005
Spy1357	grab	Protein GRAB (protein G-related α 2M-binding protein)	2.42	5.45E−05

^aShaded rows highlight significant up-regulation of specific genes in the mutant strain.

^bUDP-G-6-D, UDP-glucose-6-dehydrogenase; UDP-GPPlase, UDP-glucose pyrophosphorylase.