Table 1.

Characteristics of subjects at baseline

Predictor	N (%)
Patient age, yr
Mean ± SD	74.2 ± 5.5
Male sex	367 (97%)
Caucasian race	369 (98%)
Number of medications at baseline
Median (Interquartile range)	12 (10, 16)
High-risk medications used at baseline
Glucose-lowering drug	104 (28%)
Loop diuretic	104 (28%)
Digoxin	33 (9%)
Anticonvulsant	33 (9%)
Any Beers criteria drug	28 (7%)
Warfarin	18 (5%)
Benzodiazepine	19 (5%)
Number of high-risk medications at baseline ‡
0	171 (45%)
1	120 (32%)
2 or more	86 (23%)
Number of new medications present at 12 month follow-up	2 (1, 4)
Median (Interquartile range)
Self-reported health score
Median (Interquartile range)	75 (50, 80)
IADL dependencies *
Fully independent	254 (67%)
Mild dependence	73 (19%)
Moderate or severe dependence	50 (13%)
Geriatric conditions
Cognitive impairment	54 (15%) †
Depression	54 (14%)
Visual impairment	47 (12%)
Incontinence	29 (8%)
Constipation	23 (6%)
Falls or gait instability	6 (2%)
Geriatric burden score *
0 (no geriatric condition)	151 (40%)
1 (1 geriatric condition)	110 (30%)
≥ 2 (2 or more geriatric conditions)	110 (30%)
Other comorbid conditions
Chronic renal insufficiency	32 (8%)
Heart failure	31 (8%)
Number of comorbid conditions
Median (Interquartile range)	11 (8, 14)
Study group
Control	175 (46%)
Intervention	202 (54%)

^*Geriatric burden score calculated as one point for each geriatric condition present, plus 1 point for mild dependence in IADLs and 2 points for moderate dependence.

^†N=371 for assessment of cognitive impairment

^‡Not counting Beers criteria drugs (to prevent double-counting, since certain benzodiazepines and higher-dose digoxin prescriptions are counted as Beers criteria drugs).