Table 3.

Mycophenolate Pharmacokinetics During IV and PO Administration in week 1 of treatment¹

Route of Administration	IV (n=11)	PO (n=18)	p-value2
MMF dose 1000mg BID/750mg BID, n/n	9/2	18/0	0.143
Day post transplantation of pharmacokinetics	35 [21–81]	38.5 [17 – 74 ]	0.67
Total MPA
Trough (mcg/mL)	0.22 [0.04 – 0.62]	0.96 [0.04 – 2.54]	0.0028
AUC0–6, (mcg*hr/mL)	20.36 [9.1–37.0]	18.76 [5.86 – 44.06]	0.57
AUC0–12, (mcg *hr/mL)	21.12 [7.9 – 32.57]	24.0 [11.4 – 44.41]	0.80
Unbound MPA
Trough (mcg/mL)	0.005 [0.0 – 0.027]	0.014 [0 – 0.106]	0.03
AUC0–6, (mcg*hr/mL)	0.612 [0.262 – 1.262]	0.367 [0.093 – 1.15]	0.02
AUC0–12, (mcg*hr/mL)	0.502 [0.235– 1.018]	0.450 [0.17 – 1.33]	0.20
MPAG trough, mcg/mL	39.29 [3.89 – 89.99]	32.80 [4.6 – 163.23]	0.51
MPA unbound fraction	0.029 [0.017 – 0.042]	0.017 [0.012–0.044]	0.005

¹Data are median [range]

²p-value is comparison of IV and PO pharmacokinetics by Wilcoxon Rank Sum Test (Mann-Whitney), unless otherwise noted.

³Fisher Exact Test