Figure 2.

Mechanistic and cellular roles of cortactin tyrosine and serine phosphorylation in tumor cell motility. Tyrosine (purple) and serine (green) phosphorylation events are shown depicting direct and indirect pathways that ultimately result in N-WASp activation. The effects of cortactin serine and tyrosine phosphorylation result in common net outcomes in invadopodia function (ECM degradation), but differ in impact on lamellipodia dynamics as shown. Cortactin phosphorylated on serine and tyrosine residues is enriched in human tumors, where it likely enhances invasive and metastatic capacity.