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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Anal Chem. 2011 Mar 29;83(9):3224–3231. doi: 10.1021/ac1032325

Figure 3.

Figure 3

SHG imaging of human ovarian cancer. A) 3D SHG renderings (left panels) and H&E staining (right panels) of normal (top) and malignant (bottom) ovarian tissues. The field size for the 3D renderings was 170 μm and the histology cross sections were captured at 40x. Both the SHG and histological images reveal that the malignant tissues are characterized by a denser 3D collagen structure with lower cell density. B) Monte Carlo simulations of the measured F/B response for normal (blue) and malignant (red) ovarian tissues using measured bulk optical parameters. The best fit simulation to the data in each case is overlapped with the experimental data.