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. 2011 May 16;121(6):2264–2277. doi: 10.1172/JCI43157

Figure 3. IFN-γ is required for maximal CpG-induced cytokine storm disease expression.

Figure 3

Ifng–/– mice were treated with PBS or CpG, and data are analyzed as in Figure 1. Compared with wild-type counterparts, (A and B) Ifng–/– mice have reduced anemia and thrombocytopenia, (C) reduced splenomegaly, and (D) complete elimination of hepatic inflammation. In contrast to the experiments shown in Figure 1, there was no difference in (A and B) the degree of leukopenia or (E) hyperferritinemia. *P < 0.05. Data are representative of 3 experiments. Individual symbols each represent 1 mouse, with the horizontal lines representing the mean values.