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. 2011 May 16;121(6):2264–2277. doi: 10.1172/JCI43157

Figure 4. Blockade of late-phase IFN-γ is sufficient to ameliorate disease.

Figure 4

(A) Levels of IFN-γ were measured from mice repeatedly injected with CpG, showing a biphasic response with an early higher level followed by lower levels, comparable to what is seen on day 10 (Figure 2A). (B and C) Mice were treated with PBS alone (PBS) or repeated CpG injections along with an IFN-γ–neutralizing antibody from day 0 (full blockade) or day 3 (second-phase blockade) or with an irrelevant isotype antibody (no blockade). (B) Cell counts were measured at sacrifice on day 10. (C) Spleen size (ratio of splenic weight to total body weight) was assessed at sacrifice. Data are representative of 2 experiments. Individual symbols each represent 1 mouse, with the horizontal lines representing the mean values.