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. 2011 May 23;121(6):2413–2421. doi: 10.1172/JCI43703

Figure 2. Phox2b Cre deletion of Lepr increases rate of weight gain.

Figure 2

(A) Weights of PC flox and flox mice were followed over time on chow diet (n = 20). Analysis of the rate of weight changes demonstrated a significant increase in rate of weight gain in the Lepr-deleted mice (95% confidence interval: PC flox [slope, 0.6095 to 0.7058 g of body weight per week] versus flox [slope, 0.5089 to 0.5961 g of body weight per week], P < 0.001). Individual data points suggest a trend toward significant difference in body weight at the end of the study (P < 0.07). (B) At 6 weeks of age, no difference in body composition was observed. (C) A trend toward an increase in body fat percentage was observed at the end of the body weight study, with PC flox–deleted mice showing an increase in adiposity (n = 10, P < 0.10).