Figure 6. Effect of hindbrain Lepr deletion on CCK- and leptin-induced food intake and body weight.

(A) CCK was injected i.p. (20 μg/kg) in PC flox and flox control mice after an overnight fast. Both PC flox and control flox mice consumed significantly less food over a 24-hour period (1-way ANOVA, P < 0.05) compared with that of saline-injected controls. There was no difference between genotypes. Leptin, delivered by osmotic minipump at a rate of 1 μg/d for 7 days, significantly reduced (B) food intake and (C) body weight in both PC flox and control flox mice, relative to that of controls.