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. 2011 May 23;121(6):2242–2253. doi: 10.1172/JCI44031

Figure 9. Intestinal epithelial expression of EGFR is required for p40’s effects on colitis.

Figure 9

Mice were treated with 3% DSS treatment for 4 days, and then mice were administered p40 for the following 3 days before mice were sacrificed to test p40’s treatment effect, as described in Figure 5. To test the effects of p40 on oxazolone-induced colitis, mice were administered oxazolone and p40, as described in Figure 8. (A and E) Colon injury scores. (D) Body weight changes after intrarectal challenge of ethanol or oxazolone. (C and F) Apoptosis was detected as described in Figure 6. The number of apoptotic nuclei per 100 crypts is shown. (B) Intestinal permeability was determined as described in Figure 7. FITC-dextran level in sera is shown. *P < 0.01 compared with water or ethanol group in Egfrfl/fl mice; #P < 0.05 compared with DSS or oxazolone group in WT mice; †P < 0.05 compared with WT mice on the same day of oxazolone treatment.