Skip to main content
. 2011 May 2;121(6):2301–2312. doi: 10.1172/JCI44824

Figure 2. Effect of TGF-β N-Ab on cardiac response to TAC.

Figure 2

(A and B) Temporal changes of FS and LV diastolic dimension (LVDd). *P < 0.05 vs. C-Ab, ANOVA. BL, baseline. (C) Heart weight/tibia length ratio (HW/TL). n = 10 (sham); 17 (TAC plus C-AB and TAC plus N-Ab). *P < 0.05 vs. sham. (D) Averaged cardiomyocyte cross-sectional area (CSA) obtained by WGA staining, 500–800 cells per heart, 10 hearts per group. *P < 0.05 vs. sham. (E) Representative Masson trichrome staining. White arrows, perivascular fibrosis; yellow arrows, interstitial fibrosis. N-Ab treatment markedly suppressed perivascular fibrosis. Scale bars: 100 μm. (F) Summary results for perivascular fibrosis area (PVF) and myocardial fibrosis area (MFA). n = 8 (sham); 17 (TAC plus C-Ab and TAC plus N-Ab). *P < 0.05 vs. sham; †P < 0.001, ‡P < 0.05 vs. TAC plus C-Ab.