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. 2011 May 9;121(6):2422–2426. doi: 10.1172/JCI45027

Figure 2. HFD-induced obesity causes impaired glucose tolerance and insulin secretion in βGHRKO mice.

Figure 2

(A) Body weight of male control and βGHRKO mice fed regular chow (RC) or HFD. (B) GTT in male mice after 24 weeks on HFD. βGHRKO mice did not exhibit first-phase GSIS (C), but displayed normal first-phase arginine-stimulated (Arg-stimulated) insulin secretion (D). Numbers in parentheses indicate sample size. (E) HFD-induced islet hyperplasia is shown by immunostaining using anti-insulin antibody. Scale bars: 200 μm. (F) β Cell mass was quantified in insulin-stained pancreas sections. (G) GSIS in isolated islets from obese mice in response to different glucose (Glu) concentrations and in the presence of KCl or glibenclamide (Glib). (H) Arginine-simulated insulin secretion in isolated islets from obese mice. *P < 0.05.