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. 2011 Jun 1;121(6):2118–2125. doi: 10.1172/JCI45680

Figure 1. Three modes of insulin granule dynamics.

Figure 1

(A) Old face. Predocked granules are fused to the membrane by stimulation. (B) Restless newcomer. Granules are newly recruited and immediately fused to the plasma membrane by stimulation. (C) Resting newcomer. Granules are newly recruited, docked, and fused to the plasma membrane by stimulation. Sequential images (1 μm × 1 μm) acquired every 300 ms indicate insulin granule dynamics. Flash indicates fusion events of insulin granules. Reproduced from Proceedings of the National Academy of Sciences of the United States of America (25).