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. 2011 May 23;121(6):2278–2289. doi: 10.1172/JCI46322

Figure 2. Angpt1 is critical in early vascular development.

Figure 2

Simplification of the cardiac trabeculation pattern of E10.5 Angpt1del/del embryos as shown by immunohistochemistry for (A) Ng2 (scale bar: 100 μm) and (B) Desmin (scale bar: 100 μm). (C) Dissection microscope photos show that Angpt1del/del embryos are markedly growth restricted at E10.5 and have disorganized vasculature as evident in embryos carrying a Kdr-GFP transgene reporter (scale bar: 1 mm).