Figure 7. Model for Angpt1 function during vascular activation.

Schematic model showing the importance of Angpt1 as an inhibitor of disease progression in the case of vascular activation that occurs in development or disease. In the absence of Angpt1, Angpt2, Vegfa, and Tgfb, actions are unopposed, resulting in more aggressive injury in disease or a larger number and diameter of vessels in development.