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Survival curves for Lmna+/+, LmnanPLAO/+ and LmnanPLAO/− mice. The survival time for male LmnanPLAO/− mice was shorter than for Lmna+/+ or LmnanPLAO/+ mice (n = 4 for each group) (p = 0.002). Previous studies showed that male LmnanPLAO/nPLAO mice had an average survival time of 38.5 weeks (a milder phenotype than LmnanPLAO/− mice),33 suggesting that nonfarnesylated prelamin A is a poorly functioning lamin.
