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. Author manuscript; available in PMC: 2011 May 31.
Published in final edited form as: Science. 2010 Oct 1;330(6000):88–90. doi: 10.1126/science.1193162

Figure 1.

Figure 1

Infection response genes (IRGs) in the mosquitoes Culex quinquefasciatus (Cq), Aedes aegypti (Aa) and Anopheles gambiae (Ag). (A) Shared and unique infection response genes in C. quinquefasciatus infected with a filarial worm, bacteria, or virus. (B) Proportions of shared and unique IRGs post-infection with viruses (1), filaria (2) or bacteria (3) in C. quinquefasciatus and A. aegypti, in C. quinquefasciatus and A. gambiae (4), and in all three species (5); and common IRGs in C. quinquefasciatus, A. aegypti, and A. gambiae (6). (C) Orthology relationships for IRG sets (Rows 1–6). IRGs with orthologs in at least 20 arthropod species were classified as Universal, as compared to Non-Universal or Mosquito-Specific. Gene copy-number counts distinguish mostly single- and multi-copy orthologous groups. IRG sets 1–6 were compared to 10,083 mosquito OGs (Row M) to identify significantly greater or smaller (asterisks) proportions (Fisher's Exact Tests: p<1e-5). (D) Consensus functional categories of universal single-copy (left) and multi-copy (right) orthologous groups of IRG sets Rows 1–6, and all mosquito groups (Row M). Functional groups are described in SOM, and (24). Each set of IRGs is described in Supplemental Tables S7–12.