Table 2. Vaccination results of mice vaccinated with SjTSP-2e against challenge infection with Schistosoma japonicum cercariae.
| Trial | Worm burden | Eggs in whole liver | Eggs in one gram of faeces | ||||||||||
| Protein | Range (worm pairs) | Mean ± SD | Med | Redu (%) | P value | Mean ± SD | Med | Redu (%) | P value | Mean ± SD | Med | Redu (%) | P value |
| Trial 1 (HDC) | |||||||||||||
| Thi | 18–29(7.8) | 23.2±3.1 | 22 | - | - | 53488±16407 | 59508 | - | - | ND | - | - | |
| Sj-TSP2 | 3–14(3.9) | 15.4±3.2 | 14 | 36.4 | 0.0004 | 37868±16286 | 43764 | 26.5 | 0.019 | ND | - | - | |
| Sm-TSP2 | 4–18(4.9) | 19.1±4.4 | 19.5 | 11.4 | 0.032 | 40041±32551 | 28743 | 51.7 | 0.075 | ND | - | - | |
| Trial II (HDC) | |||||||||||||
| Thi | 10–32(10.1) | 20.0±6.3 | 21 | - | - | 97407±36537 | 112216 | - | - | 4791±2969 | 5714 | - | - |
| Sj-TSP2 | 2–23(6.8) | 14.3±6.0 | 16.5 | 21.4 | 0.065 | 95833±31066 | 99339 | 11.5 | 0.842 | 4509±2870 | 4067 | 28.8 | 0.806 |
| Sm-TSP2 | 2–24(6.8) | 15.7±7.6 | 16.5 | 21.4 | 0.306 | 90671±49179 | 107768 | 4.0 | 0.968 | 4537±5752 | 3341 | 41.5 | 0.326 |
| Trial III (LDC) | |||||||||||||
| Thi | 2–11(2.7) | 8.33±2.8 | 9 | - | - | 21176±16629 | 23966 | - | - | 637±643 | 560 | - | - |
| Sj-TSP2 | 6–12(1.6) | 8.30±2.1 | 7.5 | 16.7 | 0.679 | 20513±23301 | 10921 | 54.4 | 0.326 | 450±561 | 179.3 | 68.9 | 0.251 |
| Sm-TSP2 | 3–10(1.5) | 7.30±2.6 | 7.0 | 22.2 | 0.266 | 11726±13051 | 6962 | 70.9 | 0.067 | 378±356 | 340 | 41.0 | 0.235 |
Note: Thi, thioredoxin, as tag protein expressed in E. coli was used as a control protein. Sj-TSP2, Sj-TSP-2e; Sm-TSP2, Sm-TSP-2. Med, median; Redu, reduction = (1-number of median worms or eggs in experimental group/number of median worms or eggs in control group)×100%; ND, no data. HDC, high dose challenge with 35 cercariae; LDC, low dose challenge with 12 cercariae.