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Genetic crosses. B6 and D2 jck/+ mice were mated and F1 progeny sacrificed between 6 and 7 weeks of age and scored for the presence of abnormal kidneys. As shown in Fig. 2, these affected kidneys were uniformly small in size. Several F1 jck/+ mice were reserved for intercross analysis and used to generate an F2 population. Affected kidneys from this population showed wide variation in size (Fig. 2).
