Table 1.
Kidney Weight by Genotype
| D1Mit30 | D4Mit286 | |||
|---|---|---|---|---|
| BB | BD | DD | ||
| D2.B6 chr1: | BBa | 1.11 ± 0.54 (32) | 1.52 ± 0.85 (44) | 2.21 ± 0.93 (18) |
| F2: | BB | 0.55 ± 0.11 (4) | 1.36 ± 0.53 (14) | 1.81 ± 0.57 (6) |
| F2: | BD/DDb | 0.59 ± 0.35 (9) | 0.67 ± 0.38 (26) | 0.79 ± 0.44 (11) |
The mean kidney weight ± S.D. is shown for various genotypic classes of the paired markers D1Mit30 and D4Mit286 (which represent QTL peaks) in the (D2.B6 chr1 congenic × B6) F2 cohort (labeled D2.B6 chr1) described in this report and in a (B6×D2)F2 population (labeled F2) generated previously (Iakoubova et al. 1995). (BB) homozygous B6; (BD) heterozygous B6/D2; (DD) homozygous D2; (N) sample size.
a
For D1Mit30, the parental D2.B6 congenic strain is homozygous B6 so this is the only possible genotype class in the (D2.B6 congenic × B6) F2 cohort.
b
In the (B6×D2)F2 cohort the heterozygous B6/D2 and homozygous D2 classes are merged (BD/DD) because the modifying effect only occurs when this locus is homozygous B6.