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. 2011 Jul 1;204(1):154–163. doi: 10.1093/infdis/jir214

Figure 3.

Figure 3.

The percentage of CD14+CD16+ monocytes and CD8+HLA-DR+CD38+ T lymphocytes correlates with sCD163. Peripheral blood mononuclear cells (PBMCs) from 8 patients with chronic human immunodeficiency virus (HIV) infection (Chronic HIV+) before antiretroviral therapy (Pre-ART) (closed circles) and 9 patients after 3 months of antiretroviral therapy (3mos ART) (2 sets of samples were from matched patients) as well as PBMCs from all 14 HIV-infected individuals with early infection (Early HIV+) (open circles) obtained Pre-ART and 3mos ART were examined. Flow cytometry analysis was used to determine the percentage of CD14+CD16+ monocytes (A, B), the median fluorescence intensity (MFI) of CD163 on CD14+CD16+ monocytes (C, D), and the percentage of activated CD8+HLA-DR+CD38+ T lymphocytes (E, F) in all PBMC samples. In A, C, and E, nonparametric Mann-Whitney t tests were used where a P value of ≤ .05 is significant. For the Early HIV+ samples, paired t tests were used, because all samples were matched Pre-ART and 3mos ART. In B, D, and F, the correlations were performed with both Early HIV+ samples (open circles) and Chronic HIV+ samples (closed circles). B, the percentage of CD14+CD16+ monocytes significantly correlated to plasma sCD163. D, the expression level of CD163 on CD14+CD16+ monocytes inversely correlated to plasma sCD163. F, the percentage of activated CD8+HLA-DR+CD38+ T lymphocytes significantly correlated to plasma sCD163 level. The r and P values shown are for the overall correlation, including both patients with recent infection and patients with chronic infection. r = Spearman's correlation coefficient, P value of ≤ .05 is significant.