Table 4.
Univariate and Multivariate Analysis for Factors Associated With Kidney Tubular Dysfunction in Human Immunodeficiency Virus–Positive Patients Treated With Tenofovir (TFV)
| Covariate | R2 | Univariate P | Multivariate P |
| rs700008 | NAa | .3 | … |
| rs41271273 | NA | .6 | … |
| rs45535935 | NA | .2 | … |
| rs45480693 | NA | .6 | … |
| rs9349256 | NA | .02b | … |
| rs2277122 | NA | .4 | … |
| rs2185631 | NA | .3 | … |
| rs2487663 | NA | .4 | … |
| rs41271275 | NA | … | … |
| rs41281802 | NA | .6 | … |
| rs2125739 | NA | .05b | … |
| rs2125740 | NA | .5 | … |
| rs41281804 | NA | … | … |
| rs6901992 | NA | … | … |
| GGC-CGTC haplotype carriage | .02 | .01b | .06c |
| Age | .1 | .06 | .04b |
| Sex | .03 | .4 | .2 |
| Duration of therapy | .02 | .2 | .06 |
| Body mass index | .2 | .8 | .7 |
| TFV plasma levels | .3 | .006b | Not includedd |
| Viral load | .2 | .3 | .3 |
NOTE. a NA, not applicable.
b
Significant differences (P < .05)
c
GGC-CGTC carriage was included in the multivariate model instead of individual ABCC10 single-nucleotide polymorphisms.
d
TFV plasma levels were not included in the multivariate model because they were available only for a subset of patients.