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. 2011 May 31;6(5):e20559. doi: 10.1371/journal.pone.0020559

Figure 2. Nonhistaminergic itch requires Pirt.

Figure 2

(A, B) CQ (200 µg) induces significantly less scratching behavior in Pirt−/− mice (n = 9) than WT controls (n = 8). (C) A smaller percentage of Pirt KO neurons respond to CQ (1 mM) compared to WT (n = 5 per genotype). (D, E) The 5HT2-selective agonist α-Me-5HT (30 µg) produces decreased scratching in KO mice (n = 8; WT, n = 13). (F) Responses to 5HT (10 µM) are unchanged in Pirt KO DRG neurons (n = 4 per genotype). * p<0.05, ** p<0.001, *** p<0.0001; two-tailed unpaired t-test.