Figure 7. Schematic presentation of the effect that topological gap junction connectivity can have on the regulation of activity in networks that are prone to seizing.

For mild perturbation of activity (low noise intensity, blue region), an increase in gap junction connectivity can offset the effect of perturbation and restore low firing rate, thus suppressing potential seizures. On the other hand, for strong perturbation (strong noise intensity, red region), an addition of gap junctions is likely to result in seizure escalation.