Figure 1. HO-1 haploinsufficiency disrupts erythrocyte parameters in the peripheral blood.

Lethally irradiated mice were transplanted with 2×10⁷ hmox ^+/+ or hmox ^+/− BM cells. Peripheral blood was drawn at each given time-point post-engraftment and was analyzed for the reticulocyte count (A), hematocrit percentage (B), RBC count (C), and hemoglobin level (D). The ratios of the RBC counts, hematocrit percentages, and hemoglobin levels of the hmox ^+/− to hmox ^+/+ genotypes are plotted in (E) using the same data shown in (B-D). The mean ± SEM is shown for five mice per genotype; *P≤0.05, **P≤0.01.