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. 2011 May 31;6(5):e20676. doi: 10.1371/journal.pone.0020676

Figure 2. LTP is L-type calcium channel-dependent in aged control-fed mice but NMDAR-dependent in aged NAC-fed mice.

Figure 2

(A and B) fEPSP slope in aged NAC-fed mice in control (blue •, n = 7) and with APV (red ▾, n = 6) or with nimodipine(green ▾, n = 9) in response to HFS. Averaged fEPSP traces inset. (C) Summary data: in NAC–fed mice LTP was blocked by APV (P<0.001) but not by nimodipine (P = 0.75). (D and E) fEPSP slope in aged control-fed mice in control conditions (blue •, n = 8) and with APV (red ▾, n = 5) or with nimodipine (green ▾, n = 7) in response to HFS. Averaged fEPSP traces inset. (F) Summary data: LTP in aged, control-fed mice was blocked by nimodipine (P = 0.002) but not by APV (P = 0.24). Scale bars: 10 ms, 0.4 mV. All data are expressed as mean ± s.e.m.