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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Curr Opin Genet Dev. 2011 Jan 19;21(3):349–353. doi: 10.1016/j.gde.2010.12.007

Figure 2.

Figure 2

Fine mapping of modifier QTL using interval-specific congenic strains. The QTL interval from the severely affected strain (donor; grey) is introgressed on the resistant strain background (recipient; black) by selective genotyping and breeding for multiple generations (≥5). Several lines are generated that carry varying donor-derived segments in the QTL interval. Each interval-specific congenic line is tested to determine the effect on the mutant phenotype. In this example, the modifier is localized to the region of overlap between the two lines that confer the modified phenotype.