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. Author manuscript; available in PMC: 2012 Jun 13.
Published in final edited form as: Brain Res. 2011 Apr 20;1395:1–11. doi: 10.1016/j.brainres.2011.04.024

Table 1.

Thermal behavioral response in animals treated with RSA 504, RSA 601 and naloxone Thermal hypersensitivity was determined by paw withdrawal latencies to infrared radiant heat applied to the plantar aspect of the hind paw of male Sprague Dawley rats. The analgesic properties of RSA 504 (RVM; 60 ng/0.5μl) and RSA 601 (RVM; 60 ng/0.5μl) were compared with that of morphine sulfate (RVM; 60 ng/0.5μl) both with and without pretreatment (−20min) of naloxone (subcutaneous; 10mg/kg) and with pre-administration (−10min) of CCK-8sulf (RVM; 30 ng/0.5 μL). (*, **, ***, ****, or *****) denote significance when compared to baseline. (†or ††) denote significance when compared to administration of RSA 504 alone. (††† or ††††) denote significance when compared to administration of RSA 601 alone.

Compound Paw Withdrawal Latency (Sec ± SEM) SEM n
Baseline 20.74 0.29 24
Morphine Sulfate (MS) 30.54* 2.83 7
Naloxone (NX) 19.16 1.10 7
MS + NX 18.70** 3.72 6
Cholecystokinin (CCK) 12.32*** 1.49 6
RSA 504 26.52**** 1.79 6
RSA 504 + CCK 22.35† 0.30 6
RSA 504 + CCK + NX 20.15†† 0.55 6
RSA 601 24.21***** 2.52 8
RSA 601 + CCK 21.76††† 1.27 6
RSA 601 + CCK + NX 20.81†††† 1.30 6