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. 2011 Feb 4;17(5-6):502–507. doi: 10.2119/molmed.2010.00074

Figure 2.

Figure 2

Histological grading of colonic and rectal tissue injury in DSS-treated WT and MFG-E8 deficient mice. WT C57BL/6J mice and MFG-E8 deficient mice (male, 6–10-wks-old) were subjected to DSS treatment as described in the Figure 1 legend. They were euthanized at the time points as indicated. Colonic and rectal tissues were processed for routine histology and stained with H&E. Slides were examined by using the score system as described in Materials and Methods in a doubleblind fashion. (A) Colonic inflammatory response. (B) Crypt-epithelial injury in colon. (C) Rectal inflammatory response. (D) Crypt-epithelial injury in rectum. Results are expressed as mean ± SEM, n = 5. *, P < 0.05 MFG-E8 knockout versus WT mice; **, P < 0.01 MFG-E8 knockout versus WT mice. KO, MFG-E8 knockout; ND, not detected.