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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Anal Chem. 2011 May 3;83(11):4118–4125. doi: 10.1021/ac200267t

Figure 1.

Figure 1

Design and fabrication of a controlled release microarray system for chemical screening. A) Micromolding of PEGDA by UV photopolymerization into arrayed microwells. B) Fabrication of a chemical-laden hydrogel microarray by robotic printing. C) Cell seeding in arrayed microwells. D) Alignment and sandwiching of arrayed chemical-laden hydrogels and cell-seeded microwells. E) Drug release and cell culturing for 6 – 24 hours. Close-up schematic shows the diffusion of chemicals from arrayed hydrogels into cell-seeded microwells. F) Analysis of apoptosis by fluorescence-based assay.