Figure 3.
Microarray device alignment and characterization. A) Photograph of a microarray device with arrayed chemical-laden hydrogels (red arrow) sandwiched on to arrayed microwells (yellow arrow). Alignment features are indicated with black arrows. B, C) Phase contrast images with overlaid fluorescent images of an aligned device (scale bar = 100 μm). D, E, F) Phase contrast and fluorescent images, and quantification of fluorescence of released chemicals (green is FITC-labeled dextran and red is Rhodamine B). G–K) MCF-7 viability in sealed microwells at 0, 6, 12 and 24 hour time points (Live/Dead staining with calcein-AM, green, and ethidium homodimer, red).