Table 1.
GWAS in MS
| Study | Year | Platform [SNPs passing QC] | Initial Sample Size | Replication Sample Size | Region | Gene(s) | SNPs | p-Value | OR | Reference |
|---|---|---|---|---|---|---|---|---|---|---|
| Nischwitz et al. | 2010 | Illumina [~300,000] | 590 cases 825 controls |
NR | 10q11.21 19p13.2 9q34.2 6p21.32 |
Intergenic ZNF433 VAV2 DQA1 |
rs2503875 rs3745672 rs3780792 rs9271366 |
2.00E-07 1.00E-06 1.00E-06 4.00E-17 |
1.66 7.39 1.6 2.62 |
[61] |
| Sanna et al. | 2010 | Affymetrix [6,607,266] (imputed) | 882 cases 872 controls |
1,775 cases 2,005 controls |
6p21.32 3q13.11 |
HLA-DRB, HLA-DQB1 CBLB |
rs2040406 rs9657904 |
1.00E-20 2.00E-10 |
2.05 1.4 |
[62] |
| Jakkula et al. | 2010 | Illumina [297,343] | 68 cases 136 controls |
4,570 cases 10,143 controls |
17q21.2 6p21.32 |
STAT3 HLA |
rs744166 rs3135338 |
3.00E-10 2.00E-25 |
1.15 3.43 |
[63] |
| Bahlo et al. | 2009 | Illumina [302,098] | 1,618 cases 3,413 controls |
2,256 cases 2,310 controls |
10p15.1 20q13.12 16p12.1 1p22.1 1p13.1 6p21.32 8q24.21 12q14.1 |
IL2RA CD40 NR EVI5, RPL5 CD58 HLA-DRB1 ASAP1, DDEF1 METTL1, CYP27B1 |
rs2104286 rs6074022 rs8049603 rs6604026 rs1335532 rs9271366 rs6984045 rs703842 |
7.00E-06 1.00E-07 1.00E-06 3.00E-06 1.00E-07 7.00E-184 2.00E-06 5.00E-11 |
1.16 1.2 1.19 1.17 1.28 2.78 1.59 1.23 |
[64] |
| De Jager et al.* | 2009 | Affymetrix & Illumina [~2.56 million] (imputed) | 2,624 cases 7,220 controls |
2,215 cases 2,116 controls |
6p21.32 1p13.1 6p22.1 3q25.33 10p15.1 12p13.31 2q22.1 12p13.31 16p13.13 5p13.2 16q24.1 11q12.2 5p13.1 12q24.31 10q22.3 |
HLA-DRB1 CD58 HLA-B IL12A IL2RA TNFRSF1A CXCR4 TNFRSF1A CLEC16A IL7R IRF8 CD6 PTGER4 MPHOSPH9 ZMIZ1 |
rs3135388 rs2300747 rs2523393 rs4680534 rs2104286 rs4149584 rs882300 rs1800693 rs11865121 rs6897932 rs17445836 rs17824933 rs6896969 rs1790100 rs1250540 |
4.00E-225 3.00E-10 1.00E-17 6.00E-06 9.00E-08 5.00E-06 1.00E-07 2.00E-11 2.00E-07 2.00E-06 4.00E-09 4.00E-09 2.00E-07 7.00E-07 2.00E-06 |
2.75 1.3 1.28 1.12 1.15 1.58 1.19 1.2 1.15 1.12 1.25 1.18 1.1 1.11 1.12 |
[29] |
| Baranzini et al. | 2008 | Illumina [551,642] | 978 cases 883 controls |
NR | 13q31.3 9p22.2 8p23.2 12q12 3q23 4q35.1 20p13 2p25.1 3q24 2q14.2 |
GPC5 SH3GL2 CSMD1 PDZRN4 SLC25A36 MGC45800 C20orf46 DDEF2 ZIC1 EN1 |
rs9523762 rs1755289 rs1529316 rs1458175 rs908821 rs7672826 rs397020 rs1109670 rs1841770 rs651477 |
1.00E-06 3.00E-06 2.00E-06 2.00E-06 3.00E-06 8.00E-06 8.00E-07 9.00E-06 8.00E-06 7.00E-06 |
1.36 1.35 1.36 1.34 1.37 1.37 1.41 1.38 1.34 1.38 |
[23] |
| Comabella et al. | 2008 | Affymetrix[428,867] (pooled) | 242 cases 242 controls |
375 cases 375 controls |
6p21.32 | HLA-DRB1 | rs3129934 | 9.00E-11 | 3.3 | [65] |
| Hafler et al.. | 2007 | Affymetrix [334,923] | 931 trios 2,431 controls |
609 trios 2,322 cases 2,987 controls |
9q33 6p21.32 16p13.13 10p15.1 5p13.2 1p22.1 |
DBC1 HLA-DRA KIAA0350 IL2RA IL7RA RPL5 |
rs10984447 rs3135388 rs6498169 rs12722489 rs6897932 rs6604026 |
8.00E-06 9.00E-81 4.00E-06 3.00E-08 3.00E-07 8.00E-06 |
1.17 1.99 1.14 1.25 1.18 1.15 |
[66] |
*
Meta-analysis