Table 2.
Genes shared by at least three diseases at (aggregate) p< 10−4
| Gene | Chr | Description | Crohn’s | RA | T1D | Celiac | MS | SLE | Ps |
|---|---|---|---|---|---|---|---|---|---|
| PTPN22* | 1 | Protein tyrosine phosphatase, non-receptor type | 10−8 | 10−90 | 10−226 | 10−5 | |||
| IL23R | 1 | Interleukin 23 receptor | 10−102 | 10−4 | 10−7 | ||||
| NRXN1 | 2 | Neurexin 1 isoform beta precursor | 10−4 | 10−4 | 10−4 | ||||
| KIAA1109 | 4 | Hypothetical protein LOC84162 | 10−5 | 10−12 | 10−5 | ||||
| EPHA7 | 6 | Ephrin receptor EphA7 | 10−4 | 10−4 | 10−5 | ||||
| TRIM27 | 6 | Tripartite motif-containing 27 | 10−5 | 10−6 | 10−11 | ||||
| TNFAIP3* | 6 | Tumor necrosis factor, alpha-induced protein 3 | 10−5 | 10−20 | 10−11 | 10−11 | |||
| TNKS | 8 | Tankyrase | 10−4 | 10−4 | 10−6 | ||||
| C20orf42 | 20 | Fermitin family homolog 1 | 10−5 | 10−4 | 10−4 |
*
Genes involved in 4 diseases.